Summary: while this scanner claims to be compatible with mac os x (i tried to use the scanner with both 10.3.8 and 10.3.9), it absolutely does not work. when i downloaded new drivers for it from the epson website (while using 10.3.9) it caused an unknown program to run all the time--it was epson smart panel--and i had to buy norton disk doctor software to fix it. the software can cause, in the words of the norton disk doctor, "major problems" on your hard drive.
Summary: Don't want to get into all the details here but suffice it to say I have spent about 12 hours trying to get the bundled software to recognize the twain driver. Third party software vuesoft and silverfree work fine. A search of newsgroups and photo sites shows that I am not the only one with this problem. You buy a scanner and are dependent on the software working (just like a printer or computer). Scanner drivers are propriatary so if they don't work you are out of luck.