Summary: Video card - it's picky on which video card it wants to accept. The NVIDIA 6xx and 7xx seems to work great, but anything from older generations may see some strange and unexplained glitches that seemingly suggest the video card is at fault, when it's not.
Pros: Before I start, it must be said that this board isn't for the average DIY'er who "claims" high tech knowledge when the best they can do is assemble a PC and fiddle with numbers. This is a server grade board. You can't use an i7 on this board. You can't really overclock here. A lot of flack this mobo has taken here is from incompetence and inexperience from these misguided folks. A MINIMUM of 900w power supply with high +12A rails is necessary to even attempt to boot t...
Cons: The BIOS - though granular, AMI did a bad job with this BIOS; looks like something from 2001, really. It's functional, but come on, at least clean it up a bit. Also, the granularity is a double-edged sword - one wrong setting, and the system won't POST. This is where I believe got most people - a ton of options here aren't available on your run-of-the-mill board. Change one wrong value and you'll have to reset BIOS using the jumper method.
Summary: A really solid mobo. Running with dual E5-2620s and 64 GB and a shed load of disks and it has been running faultlessly. I am a fan of Asus mobos and rate them generally very highly across the board (no pun intended!) as being reliable and easy to configure and this one is no exception.