Summary: Synapse is a finicky program. Without it, the side buttons are nothing but replacement number row keys on your keyboard. When I first installed synapse everything was fine, macros were working and all that. After a restart my mouse wouldn't move, I'd have to uninstall synapse in order for it to function again. The mouse buttons were working, but it refused to move.
Pros: The mouse texture feels great. It doesn't attract dead skin cells or sweat at all. There was a problem on my older Naga Hex where I'd have to clean off the edge of the L/R clicks every few hours under heavy use.
Cons: Not sure if it's just my mouse but sometimes the right click doesn't actually click, this was happening right out of the box before any real usage and is still happening. It's essentially already clicked down. You can click with the same amount of force and you will get the click, but you won't feel it or hear it. Whenever this happens I have to rapidly right click to get it back to normal. This happens at least 2 times a day.