Summary: I have used more than a dozen "gaming" mice and this mouse has been the most comfortable for me. Its 3 thumb buttons are very easy to access and hard make any mistakes in pressing them. The dpi buttons (or programmed to whatever you like) are not as comfortable to press and I rarely use them besides as dpi controls.
Pros: Very comfortable, One of the best placement of thumb buttons I have seen.
Cons: Styling is arguably worse than its predecessor., Could use more profile storage
Summary: Like most, I've owned several gaming mice, but have always been on the lookout for a mouse the feels like my old optical G series from years ago.. It had the best feel! I've owned and tossed several razer mice, even a few Logitech mice that "just don't feel right", and finally discovered the G500S which is awesome! I haven't experienced the issues described by other folks, not so say that their issues aren't legitimate.
Summary: I bought the Razer Taipan mouse last month and gave it a serious try. It was slightly more expensive than this mouse and it was lacking a lot of the features this mouse has. I returned the Taipan in favor of this mouse and haven't looked back since. The scroll wheel on this mouse is really convenient, and the DPI indicator is very useful. This mouse is solid, comfortable, and accurate.
Pros: Feels great. Solid build quality. Mouse wheel is amazing. Looks nice and professional (as opposed to Razer mice).
Cons: Wish it had the 4 side buttons of the G700s.
Summary: I have been playing PC games since I was a child on a 286 so between myself and gaming friends I have used a wide range of mice over the years. The G500s is by FAR my favorite mouse that I have ever used. I had read other reviewers writing about the high pitch sound and thought that they must have received bad ones.
Summary: I'll start off with the cons and end on the better notes. There isn't any cons... That's all i can say. The supposed high-pitched sound that emits from the mouse is too quiet to hear from any distance besides purposely putting it up to your ear and trying to hear it. Any cooling fan from any PC or laptop will easily drown out the slight noise that could possibly be heard.