Summary: I use this on a CAD workstation 8 hours per day. Very high quality mouse and my wrist and fingers appreciate the ergonomics. At my company this is the mouse of choice for engineers with wrist problems. The extra buttons are nice but the best feature is being able to adjust the resolution on the fly. When I need to do ultra precision work I don't even need to move my hand. The layout is such that I have never hit a button by accident.
Summary: Positive Points: Very easy install. Each person can tweak the mouse-pointer settings to suit themselves. Negative Points: I chose this "small" mouse that was reportedly a good fit for a woman's hand. I can use it but it is larger than I expected. The Evoluent mouse should be smaller still for my hand. The new mouse doesn't make my downtime game playing easier at all. I switch back and forth from my regular mouse and the Evoluent.
Summary: Takes a short while to get used to using this when coming from a traditonal mouse. The tendency to use the desk as a palm rest (when using a traditional mouse) goes away pretty quickly which should alleviate some discomfort. Clicking on the middle button is much easier than clicking on a middle mouse wheel, but either can be used for middle mouse button. Mouse scrolling works as you'd expect. The sensitivity adjustment buttons are minimally useful.
Summary: It's very easy to use. I don't know how much it helps my wrist, but it feels like it's keeping things from getting worse. I'm a graphic designer, and often need to use subtle movements with the mouse, I'm finding that I have no difficulties doing this with the verticle mouse.
Summary: This mouse works fine in general. The middle button is a little erratic for autoCAD but with each new mouse it is a monumental task to get the buttons to perform the ay you want in CAD so not unexpected. By and large the rest of the buttons worked fine from the beginning. I did download the program that allows you to assign button functions to get it where I wanted.
Summary: At first I ordered the VM4RW because I wanted a wireless mouse, but as I feared it proved to be too large for my small hand. This mouse fits my hand perfectly (I measure 6.5" from the tip of my middle finger to the crease in my wrist) and the wire has not gotten in the way (The only reason I gave it 4 stars is due to it being wired. If it was wireless it'd definitely get 5 stars!). It's very easy to set up and use and I don't have to consciously try to hold onto it.
Summary: This mouse is very nice for anyone who gets any sort of finger/wrist pains after prolonged usage of a mouse. The angle your hand sits at is much more natural than the usual mice, and takes a lot of stress off your wrist. The buttons are nice and responsive, but not quite as nice as my Razer Mamba.
Pros: - Vertical angle really decreases stress on the wrist, - Wrist pain is virtually gone after a week or so, - Speed controls and software definitely a plus, - Love the middle click button (and mouse wheel button can be set to anything you want), - Large mouse that fits nicely in the hand
Cons: - Still not quite the perfect shape, - Wrist hurts a tiny bit in a new spot now, - Takes some getting used to, especially in terms of how to grip it, - A bit too pricey