No, iTunes only plays well with Apple.
If this is like most creative products, then no you cannot. but there is an alternative. Blank cds come very cheap and it is easy to stack up on them w/ one purchase. just use itunes to burn whatever songs you have on the cd, then rip them to the library of your choosing(personally, i use windows media player). then put the songs from there on your player. some think this is too tedious, but i dont think so.