Summary: There's a reasonable amount of padding surrounding the main compartment, but I added an additional neoprene sleeve for extra protection.
Pros: Built very well, and sized just right for a tablet and accessories on the go. The main compartment perfectly accommodates an iPad 4, Kindle Fire HD 8.9, or Nook HD+, even while wearing an additional neoprene sleeve.
Cons: The compartments are too small for a legal pad or unfolded sheet of notebook paper, although a smaller 5x7 notepad fits easily.
Pros: Really nice bag. I bought to use with the Asus TF700T and keyboard dock. Both fit very nicely with plenty of room to spare. The front pocket has room for charger and cable plus some extra smaller pockets, one specifically for a USB flash drive. plus some slots for a table pen if desired.
Cons: My only con would be that the padding on the bottom of the case seems thinner than that on the sides. I'll live.
Pros: 10.1" Transformer Prime tablet + keyboard dock fit comfortably in the main compartment. On top of that, front compartment will easily hold: notebook mouse, charger, and even a gamepad. And the front pocket will hold a 4" smartphone (vertically). Large adjustable shoulder strap keeps it securely at your side or on your back, and it's slim enough to even put a jacket on over the top of it to keep it out of the rain.
Cons: Shoulder strap could use a small bit of padding, or less abrasive edge. The front compartment opening is slightly smaller than the main compartment.