Summary: I am currently using these 301 Series V's as my front L&R speakers in a large living room with a 5.1. They are connected to a Denon 125 Watt per channel receiver that also pushes a definitive center channel, martin logan rears, and an REL subwoofer. I could not be happier with the setup. Honestly. I feel as though the softness and overall smoothness of the Bose 301's helps to fill in any gaps in sound between my other speakers.
Excerpt: I like Bose products in general. I always wanted to try 301 series. They took a couple of days to "burn in", but now they are set and work really well. I am using them in combination with an Onkyo receiver and Sony Subwoofer. Both are on the lower end of the spectrum and are clearly struggling to cope with Bose. Speakers definitely require a higher output amplifier.