What are the specs of the speakers needed. (in terms of RMS)
I run 2-5by 7's w/a 65 watt rms rating in front and 2 MTX truck wedge enclosed speakers w/8 in. woofers and a horn tweeter in each they are 15-20 yrs, old but I would guess rms is 90 to 95 watts ea.My F-300 can work them hard and loud with no clipping.Strong,Clean 300 watts. When in doubt Bobby gave a good answer.
The MRP-F300 sends 50 watts through its four channels at 4 ohms, and 75 watts at 2 ohms. The outputs can also be bridged, and in that mode the MRP-F300 will send 150 watts to a pair of subwoofers at 4 ohms. So, any full range speakers that are compatible with these frequencies (RMS wattage: 300)can be used.