Summary: I found the Sony 5300ES to be slightly more complicated to setup. When switching to a different manufacture you always expect some different nomenclatures/phrases for settings etc... though my learning curve with the 5300ES was a tad bit longer then usual. One has to understand of course this unit does offer a heck of a lot (functionally).
Summary: I purchased a 5300ES and have experienced problems with audio from a DirectTV HR250 Tivo when viewing HD channels. The audio on HDMI is reduced to just loud noise. This never happens on SD channels. The sound over the speaker outputs is always ok. My unit has a low serial number but has the green dot indicating its firmware has been upgraded. I've contacted Sony and they are going to exchange the unit.
Summary: I bought the STR-DA5300ES to replace a Denon system in about the same price range that had no HDMI capability. I have a 1080p projection system which requires HDMI for 1080p (otherwise is limited to 1/2 resolution HD, technically known as 1080i) and so I'd been looking for a receiver with decent HDMI connectivity. With six inputs and one output, this receiver fit the bill, and it was 7.1 like the Denon, so I wouldn't have to make wiring changes to the speaker setup.